MAY 17, 2022 9:00 AM PDT

On the way towards personalized medicine: Gene therapy AAV characterization by capillary electrophoresis (CE) and liquid chromatography mass spectrometry (LC-MS)

Sponsored by: SCIEX
Speakers

Abstract
Date:  May 17, 2022
Time: 9:00am (PDT),  12:00pm (EDT), 8:00pm (CEST)
 
Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmaceutical industry is rapidly expanding its capabilities to discover, design and develop these novel therapeutics. Analytical platform methods have proven to be valuable tools in biopharmaceutical processes increasing efficiency. Prior to regulatory submission, there are many aspects that require extensive characterization, including the carrier and the genetic material as well as related impurities. This presentation evaluates AAV gene therapy product characterization from the viral proteins to the genetic material, including capabilities for analyzing both, product- and process-related impurities using SCIEX CE and LC-MS analytical platform strategies.
 
Learning Objectives
  • How to ensure and monitor viral capsid, viral protein and transgene integrity reproducibly with platform methods
  • How to characterize product- and process related impurities of AAVs for viral proteins and genome
  • How to determine critical quality attributes, such as high-risk residual nucleic acid analysis posing a safety concern and post-translational modifications impacting the efficacy of the viral carrier
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 

Show Resources
You May Also Like
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
JUN 29, 2022 7:00 AM PDT
JUN 29, 2022 7:00 AM PDT
Date: June 29, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Imaging live cells is key to reveal their inner workings, dynamics, and function. Current technological advances in confo...
MAR 30, 2022 6:00 AM PDT
MAR 30, 2022 6:00 AM PDT
Targeted NGS has been instrumental in helping the healthcare community deliver on the promise of precision medicine. The Ion Torrent Genexus Integrated Sequencer has enabled targeted genomic...
MAR 23, 2022 11:00 AM PDT
MAR 23, 2022 11:00 AM PDT
Date: March 23, 2021 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEDT) In this presentation, Dr. Middleton will review the development and deployment of large-scale saliva-based COVID-19 test...
JUN 01, 2022 9:00 AM PDT
JUN 01, 2022 9:00 AM PDT
Date: June 01, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) The manufacturing process for cell and gene therapies is complex and can contain process-related impurities from multiple...
Loading Comments...
Show Resources