MAY 18, 2021 5:00 AM PDT
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HbA1c: past, present and future

Sponsored by: Abbott
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Professor of Biochemistry and Molecular Biology at the Faculty of Medicine of Reims, France
    Biography

      Prof. Philippe Gillery, MD, PhD, is Professor of Biochemistry and Molecular Biology at the Faculty of Medicine of Reims, University of Reims Champagne-Ardenne, France. He is the chair of the Laboratory of Biochemistry-Pharmacology-Toxicology and of the Biology and Pathology Department of the University Hospital of Reims, France. He is currently appointed as Chair of the Scientific Division of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and is Associate Editor of the Clinical Chemistry and Laboratory Medicine Journal. His research interests are related to the effects of nonenzymatic post-translational modifications (especially glycation and carbamylation) on protein structure and functions, and to their involvement in the pathophysiology of diabetes mellitus and other chronic diseases. He has published more than 230 articles in peer-reviewed journals.


    Abstract

    Date:  May 18, 2021

    Time: 5:00am PST, 2:00pm CEST

     

    Since its discovery in the late 60s, HbA1c, the major form of glycated haemoglobin, has been widely used in laboratories as a key biomarker of glycemic control in patients with diabetes over the four to eight weeks preceding blood collection.

    Many methods based on different principles (ion exchange HPLC, capillary electrophoresis, immunoassay, affinity, enzymatic methods) have been developed for assaying HbA1c, necessitating an international standardization which was achieved by IFCC in the 2000s. All HbA1c methods are now traceable to the IFCC reference measurement procedure, and values of calibrators are assigned by an international network of reference laboratories. The development of external quality assessment schemes together with the standardization process have deeply improved the quality of results.

    Meanwhile, several interlaboratory trials have shown that an important point in external quality assessment was the use of commutable control samples (same behavior as fresh whole blood from patients) in order to clearly assess the quality of the methods.

    Most of the analytical challenges of HbA1c assays have been addressed, especially interferences (labile HbA1c or carbamylated Hb). However, different clinical situations need to be carefully considered like chronic kidney disease, because of the modifications of red blood cell lifespan due to chronic anemia and to the possible administration of erythropoietin, and of the occurrence of competing processes like carbamylation. Another situation is the presence of a hemoglobin variant.

    The interference of the major variants has been well documented, but many less common variants may be encountered that interfere positively or negatively with results.

    Finally, besides its role as gold standard in the survey of glycemic control, HbA1c is now used in many countries as a tool for diabetes diagnosis and/or screening, being interesting for its lower variability than glucose and achievable without fasting.

     

    In this webinar, you will :

    • Discuss the different methods used for assaying HbA1C with their characteristics and performances.
    • Discuss and understand the importance of the use of commutable materials for external quality control assessment
    • Discuss the major pitfalls in HbA1c result interpretation, especially in case of renal diseases or hemoglobin variants, and the new indications of HbA1c in diabetes diagnosis.

     

     

     

     

    Webinars will be available for unlimited on-demand viewing after live event.

     

    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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