APR 08, 2021 5:00 PM CEST

Generating multi-omics atlas of CD8+ T cell exhaustion vs. dysfunctional states in immuno-oncology

Sponsored by: Miltenyi Biotec
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Assistant Professor (BOF-ZAP) at KU Leuven
    Biography

      Prof. Abhishek D. Garg is currently assistant professor (BOF-ZAP) at KU Leuven, Belgium since October 2018, and head of the Cell Stress & Immunity (CSI) Lab since February 2020. He has several years of experience in cellular and molecular immunology, cancer cell death and stress response-related immunology, cancer immunology, and immunotherapy. During his PhD, he performed front-line research on damage-associated molecular patterns and immunogenic cell death (ICD) in cancer. Thereafter he continued as a postdoctoral researcher at KU Leuven, where he pursued studies on various immunological determinants of ICD and ICD-based DC vaccines. During his postdoc, he also carried out research visits to the University of Helsinki (Finland) and De Duve Institute (Belgium) to work on different aspects of cancer cell-innate immune cell interface and the interaction of antigen-specific T cells with cancer cells. As head of the CSI Lab, Prof. Garg is aiming to effectively bridge the glaring gap between clinical (human) and preclinical (rodent models or experiments) evidence via reverse translational approaches, to facilitate translational immuno-oncology.

    • Product Manager for Sample Preparation at Miltenyi Biotec
      Biography

        Dr. Maria Delso Vallejo, is Product Manager for Sample Preparation at Miltenyi Biotec. She received her PhD in Biology at Hannover Medical School, Germany in 2018. During her PhD Maria worked as a Marie Curie Early Stage Researcher at Miltenyi Biotec, studying the ex vivo expansion of natural killer cells for their use in immunotherapy against cancer. Since 2017 she joined the Sample Preparation team at Miltenyi Biotec.


      Abstract

      DATE:  April 08, 2021

      TIME:  5:00pm CEST

       

      THIS WEBINAR WILL BE AVAILABLE FOR ON-DEMAND VIEWING AT A LATER DATE.

       

      Multi-omics involves the use of different data modalities to study multiple “omes”, such as the genome, transcriptome, epigenome, and/or the proteome, allowing an integrative approach to address complex biological enigmas. In the context of immuno-oncology, this approach enables better characterization of anti-tumor immune responses and identification of biomarkers to help tailor immunotherapeutic strategies. The success and reliability of such analyses rely on the quality of the samples. In this webinar, Miltenyi Biotec will explain how to efficiently prepare cells for genomic analysis that can be applied to other “-omic” analysis, with a special focus on the preparation of cells from tumors.

       

      Prof. Abhishek Garg from KU Leuven has years of experience studying cancer immunology and immunotherapy. Recently he led a multi-partner collaborative investigation on chronically-sensitized states of tumor-infiltrating CD8+ T cells, broadly classifying them as immunotherapy-responsive differentially exhausted, or immunotherapy-resistant severely dysfunctional. Prof. Garg will present in this webinar how they have conducted an orthogonal multi-omics exploration of exhausted/dysfunctional CD8+ T cells across existing and in-house cancer patient cohorts (>4000 patients across different human cancers). This study comprehensively expands clinical knowledge on CD8+ T cell- states, and provides crucial computational/technical resources to guide the design of future T cell-targeting immunotherapy clinical trials.

       

      Learning Objectives:

      • Learn which steps are important in the preparation of cells prior to genomic analysis, and how to apply these steps to efficiently prepare cells from tumors for high quality and reliable genomic analysis.

      • Interpret the concept of CD8+ T cell exhaustion/dysfunction as a “continuum of differential states” rather than a definitive state.

      • Decipher the importance of balanced biomarker approaches for identifying precise clinical CD8+ T cell states, to correctly guide clinical application of immunotherapies and tailor it to appropriate cancer-type/patients.

       

       


       
      LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


      Show Resources
      You May Also Like
      MAY 11, 2021 10:00 AM PDT
      Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
      C.E. CREDITS
      MAY 11, 2021 10:00 AM PDT
      Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
      Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
      DEC 02, 2020 8:00 AM PST
      C.E. CREDITS
      DEC 02, 2020 8:00 AM PST
      DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
      NOV 16, 2020 8:00 AM PST
      C.E. CREDITS
      NOV 16, 2020 8:00 AM PST
      Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
      OCT 29, 2020 6:00 AM PDT
      C.E. CREDITS
      OCT 29, 2020 6:00 AM PDT
      Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
      MAR 16, 2021 10:00 AM PDT
      C.E. CREDITS
      MAR 16, 2021 10:00 AM PDT
      Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
      NOV 18, 2020 8:00 AM PST
      C.E. CREDITS
      NOV 18, 2020 8:00 AM PST
      DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
      Loading Comments...
      Show Resources
      Attendees
      • See more